Lymphocytes force target cells to die

Specific Adherence of in Vitro Differentiated Lymphocytes to Target Cells

Blast cells which were derived from rat lymphocytes by stimulation with phytohemagglutinin (PHA), concanavalin A (Con A), or pokeweed mitogen (PWM) transformed within 2-3 days into a new type of lymphocytes when plated without mitogen on embryo fibroblast monolayers. These lymphocytes were termed secondary lyrophocytes. Upon addition of PWM to PWM-secondary lymphocytes a marked adherence to fib...

Bacterial Adhesion to Target Cells Enhanced by Shear Force

Surface adhesion of bacteria generally occurs in the presence of shear stress, and the lifetime of receptor bonds is expected to be shortened in the presence of external force. However, by using Escherichia coli expressing the lectin-like adhesin FimH and guinea pig erythrocytes in flow chamber experiments, we show that bacterial attachment to target cells switches from loose to firm upon a 10-...

Die and Let Live: Eliminating Dangerous Lymphocytes

Abul K. Abbas Immune Privilege: Preventing Immunological Immunology Research Division Injury to Vital Organs Department of Pathology The central nervous system (CNS), testes, and eyes are Brigham and Women’s Hospital said to be immunologically privileged sites because alloand Harvard Medical School geneic or xenogeneic tissues transplanted into these Boston, Massachusetts 02115 sites are not re...

Do endothelial cells eat tryptophan to die?

Correction: The Kinematics of Cytotoxic Lymphocytes Influence Their Ability to Kill Target Cells

Cytotoxic lymphocytes (CTL) have been reported to show a range of motility patterns from rapid long-range tracking to complete arrest, but how and whether these kinematics affect their ability to kill target cells is not known. Many in vitro killing assays utilize cell lines and tumour-derived cells as targets, which may be of limited relevance to the kinetics of CTL-mediated killing of somatic...